Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1424 | 1424-30401 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K70KPQT | K103H, Y181C, G190A | A98G, K101H | E40F, K43Q, I135T, R172K, D177E, G196GE, H208Y, R211K, H221Y |
| >1424-30401| codons 38-247 CTFLEQEGKISKIGPENPYNTPVFAIKKKNSTTWRKLVDFRELNKRTQDFWEVQLGIPHP GGLHKHKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFKKQNPEIVICQYMDDLYVASDLEIEQHRTKIEELRQYLWKWGFYTP DKKYQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54LV, V82A, L90M | L10F, F53L, Q58E | I15V, D60E, L63P, A71V |
| >1424-30401| codons 4-99 TLWQRPFVTIKVGGQLKEALLDTGADDTILEEMNLPGRWKPKIVGGIGGLVKVREYEQIP IEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |