Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1421 | 1421-30331 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, M46L, I54L, L90M | V32V_W, N88D | L10R, I15V, L19Q, K20T, R41K, K55KR, L63P, K70R, A71V, V77I |
| >1421-30331| codons 4-99 TLWQRPRVTIKVGGQQTEALLDTGADNTVLEEMNLPGKWKPKLIGGIGGFLRVRQYDQIP IEICGHRVIGTVLIGPTPVNIIGRDLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, Q151M | A62AV, V75VI, F116Y, K219E | K103N, Y181C | S68G, D123E, S162C, K166Q, R172K, I178L, E204Q, Q207A, R211K, F214L, L228H |
| >1421-30331| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKRKDGTRWRKLIDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYYSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQCSMTQILEPFKKQNPDLVICQYMDDLYVGSDLEIGQHRTKIEQLRAHLLKWGLTTP DEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |