Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1428 | 1428-30313 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L10I, I13V, K20I, M36I, Q61N, L63A, I64L, I93L |
| >1428-30313| codons 4-99 TLWQRPIVTVKIGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFIKVRQYDNIA LEICGHKAIGTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | T215I, K219E | Y181V | K65KE, T69N, K122E, S162A, Q207E, R211K, L228HR, P243S, V245E |
| >1428-30313| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKEKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQASMTKILEPFRKQNPDIVIVQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFITP DEKHQKEPPFRWMGYELHPDKWTVQSIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |