Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2254 | 2254-30710 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, L74LI, M184V | D67G, T215I, K219Q | K103S, G190A | K238T | K64H, T69N, V118I, K122E, I135T, G196E, Q197K, T200A, F214L, L228H, V245K |
| >2254-30710| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIHKKGSNRWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKSKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVASDLEIEKHRAKIEELRQHLLRWGLITP DQKHQKEPPFHWMGYELHPDTWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, L90M | L10F, G73T | K20I, M36V, I62V, L63P, I66L, A71V, I72T |
| >2254-30710| codons 4-99 TLWQRPFVTIKIGGQLIEALLDTGADDTILEEVNLPGRWKPKIVGGIGGFLKVRQYDQVP IELCGHKVTTTVLVGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |