Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2251 | 2251-30730 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| S48T, D121DH, K122E, I135T, E138A, K173KR, I178IM, T200A, I244V |
| >2251-30730| codons 38-247 CTEMEKEGKITKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLHEDFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRRQNPDMVIYQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPVVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10LF | I13V, I15V, R57K, L63P, I64V |
| >2251-30730| codons 4-99 TLWQRPFVTVKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVKQYDQIP VEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |