Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1927 | 1927-30527 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, Q151M, M184V | F77FL, F116Y, K219Q | K103N, Y188YH | V60I, K122E, I135T, E138A, S162C, Q197E, F214L |
| >1927-30527| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKLVDLRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYYSVPLDEDFRKYTAFTIPSTNNATPGIRYQYNVLPMGWKGSP AIFQCSMTKILEPFRKQNPDIVIYQYVDDLHVGSDLEIGEHRTKIEELRQHLLRWGLTTP DQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, I84V, L90M | G73C | L10I, I15V, L19V, K20R, M36I, L63P, I64V, I66V, I85IV |
| >1927-30527| codons 4-99 TLWQRPIVTIKVGGQVREALLDTGADDTVLEEINLPGRWKPKIVGGIGGFMKVRQYDQIP VEVCGHKAICTVLVGPTPVNVVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |