Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2137 | 2137-40728 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 53 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32IL, M46I, I47V, I54M, V82L, L90M | L33F, G73A | L10I, I13V, K55KR, I62IV, L63P, I66F, V77I, I85L |
| >2137-40728| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTLFEEMNLPGRWKPKIVGGIGGFMRVRQYD QVPIEFCGHKAIATVLIGPTPLNILGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74LI, M184V, T215Y | K219E | K103N | V108I, Y318F | S68G, K102Q, V118I, K122E, T200A, Q207E, R211K, L228H, V245K, I293V, M357T, R358K, G359GS, V365I, T386I, E399G |
| >2137-40728| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNGTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFYTPDEKHQKEPPFHWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVFYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKSA HTNDIKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWGA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |