Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2137 | 2137-31022 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 13 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | L33F, G73A | L10I, I13V, I62V, L63P, I66F, I72IT, V77I |
| >2137-31022| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTIFEEMNLPGRWKPKIVGGIGGFMKVRQYD QVPIEFCGHKATATVLIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184I, T215Y | K219E | K103N | V108I, Y318F | S68G, K102Q, V118I, K122E, I135T, I178IM, T200A, Q207E, R211K, L228H, V245K, I293V, S322ST, M357T, R358K, V365I, E399G |
| >2137-31022| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYIDDLYVGSDLEIGQHRAKIEELREHLLKWGFYTPDEKHQKEPPFHWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVFYDPTKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA HTNDIKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWGA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |