Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1877 | 1877-30602 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54IM, V82VA, L90M | V11VI, L33F, F53FL, G73S | L10I, I13V, I15IV, E34EQ, N37C, R41K, I62IV, L63P, A71AV, V77I, I93L, C95CF |
| >1877-30602| codons 4-99 TLWQRPIITVKVGGQLKEALLDTGADDTIFQEMCLPGKWKPKIVGGIGGLMKVRQYDQVP IEICGHKVISTVLIGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69T_ST, L210W, T215Y | A62V, V75I | K64R, V118VI, K122E, D123E, I135V, D177E, G196E, R211K, V245M |
| >1877-30602| codons 38-247 CTELEKEGKISKIGPENPYNTPVFVIRKKDSTKWRKLIDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYMDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |