Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1626 | 1626-30328 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L23I | L10I, T12TS, K20R, M36MI, N37D, I62V, L63P, A71V, Q92R, I93L |
| >1626-30328| codons 4-99 TLWQRPIVSIKIGGQLREAILDTGADDTVLEEIDLPGRWKPKLIGGIGGFVKVRQYDQVP IEICGHKVIGTVLVGPTPANIIGRNLMTRLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, D67N | K219E | Y181C | K43Q, K103R, K122E, Q174R, T200A, Q207E, V245E |
| >1626-30328| codons 38-247 CTEMEQEGKISKIGPENPYNTPVFAIKRKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPDIVICQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTP DEKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |