Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1623 | 1623-30320 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54A, V82A, L90M | G73S, L89V | L10I, T12K, I13V, G16E, L19I, K20I, M36I, L38F, I62V, L63H, A71V, T74S, I93L | E34E_KQY*K |
| >1623-30320| codons 4-99 TLWQRPIVKVKIEGQIIEALLDTGADDTVLEEINFPGRWKPKMIGGIGGFAKVRQYDQVH IEICGHKVISSVLVGPTPANIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70KR, M184V, T215F | A62V, T69G, K219E | A98G | D67X, I135R, S162C, Q174QK, V179I, G196E, T200A, H208HY, V245E |
| >1623-30320| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKXSGRWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKKNPDIIIYQYVDDLYVGSDLEIEQHRAKIEELRQYLLRWGFFTP DEKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |