Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1366 | 1366-30821 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46IL, I54V, V82S | L24I, K43T, F53FL | L10IV, L19I, K20R, E35D, M36I, N37NS, R41K, K55KR, D60E, L63P, I64IMV, A71V, V77I, I93L |
| >1366-30821| codons 4-99 TLWQRPVVTIKIGGQIREALIDTGADDTVLEDISLPGKWTPKLIGGIGGLVRVRQYEQIP VEICGHKVIGTVLIGPTPSNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67HN, K70R, M184V, T215F | K219Q | T39A, K43E, V60I, S68SN, T69TN, I135V, S162Y, D177G, V179I, T200A, Q207A, H208Y, R211K, K223Q, L228H, V245Q |
| >1366-30821| codons 38-247 CAELEEEGKISKIGPENPYNTPIFAIKKKNNNRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPGIIIYQYVDDLYVGSDLEIGQHRAKIEELRAYLLKWGFFTP DQKHQQEPPFHWMGYELHPDKWTVQPIQLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |