Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1359 | 1359-30729 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L210LW | T215TS, K219KN | L100LI, K103KN | T39TA, K43KE, V60I, R83RK, W88WC, I135IV, E138A, I202IV, R211K, V245EK |
| >1359-30729| codons 38-247 CAEMEEEGKISKIGPENPYNTPIFAIKKKDSTKWRKLVDFRELNKKTQDFCEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSVNNATPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKVEELRQHLWKWGFSTP DNKHQKEPPFLWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I84IV, L90LM | L10LI, T12TA, I13IV, K14KR, K20KI, E35D, M36MI, L63LP, I64V, A71AV, I72IV, P79PH, I93IL |
| >1359-30729| codons 4-99 TLWQRPIVAVRIGGQLIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYDQIP VEICGHKVVGTVLVGHTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |