Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1281 | 1281-30424 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219R | K103N | T39A, V60I, T69TN, K122E, I135M, E138Q, Q174K, N175Y, G196E, R211K, V245VE | L120L*W, V189VL, K201IV |
| >1281-30424| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKNSNKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPWDEDFRKYTAFTIPSMNNQTPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKYPDIVIYQYMDDLYLGSDLEIEQHRTVIEELRQHLWKWGFYTP DRKHQKEPPFLWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73S | L10I, K20V, L24LM, D60E, Q61E, I62IV, L63P, H69Q, A71V, I72R, V77IM | D25N |
| >1281-30424| codons 4-99 TLWQRPIVTIKIGGQLVEALMNTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYEEVP IEICGQKVRSTVLMGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |