Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2183 | 2183-30701 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69G_SG, T215Y | A62V | K103KN, Y181C | I135T, K166R, L228H |
| >2183-30701| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKDSGKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84V, L90M | L10F, L33F, G73T | I13V, L19I, L24LM, L63P, A71AV |
| >2183-30701| codons 4-99 TLWQRPFVTVKIGGQIKEALMDTGADDTVFEEMNLPGRWKPKIIGGIGGFMKVRQYDQIP IEICGHKVITTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |