Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1345 | 1345-30501 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, V82AT, L90M | K20R, E35D, M36I, N37D, R41K, R57K, I62V, L63P, A71V, I85V |
| >1345-30501| codons 4-99 TLWQRPLVTIKIGGQLREALLDTGADDTVLEDIDLPGKWKPKIIGGIGGFVKVKQYDQVP IEICGHKVIGTVLVGPTPTNIVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, L210W, T215Y | K219Q | K103N, Y181C, G190A | A98G | T39A, E40F, K65K_N, V106VI, K122E, D123N, G196E, E203K, Q207E, H208Y, K223E, L228H |
| >1345-30501| codons 38-247 CAFLEKEGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSITVLDVGDAYFSVPLDENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLEIEQHRTKIKELREYLWRWGFYTP DQKHQEEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |