Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2195 | 2195-30630 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, L90M | V32I_P, G73S, L89V | L10I, R57K, L63P, A71V, V75I, V77I, I85V, I93L |
| >2195-30630| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTILEEMNLPGRWKPKIVGGIGGFMKVKQYDQIP IEICGHKVISTILIGPTPVNIVGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, L210W, T215Y | K219DE | K103N | T39A, E44D, S48E, A98S, V118I, D123E, D177E, I178IM, T200A, E203V, Q207E, H208Y, R211K, L228H, V245E |
| >2195-30630| codons 38-247 CAELEKDGKIEKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKKNKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEMVIYQYVDDLYVGSDLEIGQHRAKIVELREYLWKWGFYTP DEKHQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |