Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1970 | 1970-30604 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | Y181C, G190A | T39K, K43E, E44D, K101Q, K102Q, V118I, K122E, S134SG, I135T, S162C, E169D, E203D, H208Y, R211K, D218E |
| >1970-30604| codons 38-247 CKELEEDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQQKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPGTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILDPFRKQNPDIVICQYMDDLYVASDLEIGQHRTKIDELRQYLWKWGFYTP ENKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, I84V, L90M | L10F, G73A | I15V, L19V, K20I, E34Q, E35D, M36I, N37S, R57K, Q61H, L63P, I64V, I85IV, Q92K |
| >1970-30604| codons 4-99 TLWQRPFVTIKVGGQVIEALLDTGADDTVLQDISLPGRWKPKIVGGIGGFMKVKQYDHIP VEICGHKAIATVLVGPTPVNVVGRNLMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |