<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1741 1741-30515 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, I84V, L90M L10F, G73NS, L89V I13V, I15V, K20T, L33L_V, R57K, I62V, L63P, A71V, I72IM, P79A  
>1741-30515| codons 4-99
TLWQRPFVTVKVGGQLTEALLDTGADDTVLEEMNLPGRWKPKIVGGIGGFVKVKQYDQVP
IEICGHKVMSTVLVGATPVNVIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75ILM, M184V, L210W, T215FY   K103N, V106VA V108VI, P225PH, K238KT T39K, K43E, E44D, K82KR, K101KR, K102KR, V118I, K122E, I135T, I142IT, I178L, V189I, G196EK, Q197E, E203D, H208Y, R211K, V245E  
>1741-30515| codons 38-247
CKELEEDGKISKIGPENPYNTPVFAIKKKNSTKWRKLMDFRELNRRTQDFWEVQLGIPHP
AGLRRNKSATILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDLVIYQYVDDLYIGSDLEIKEHRTKIDELRQYLWKWGFYTP
DKKHQKEHPFLWMGYELHPDTWTVQPIELP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006