Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2029 | 2029-30724 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IL, I84V, L90M | G73T | L10I, I15V, K20I, E35D, L63P, A71V, I85V, I93L |
| >2029-30724| codons 4-99 TLWQRPIVTIKVGGQLIEALLDTGADDTVLEDMNLPGRWKPKIIGGIGGFLKVRQYDQIP IEICGHKVITTVLVGPTPVNVVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67NS, K70R, T215F | K219Q | Y181C, G190A | T39N, K46Q, T69N, K101A, K103R, K122E, I135V, K166R, Q207DN, D218E, L228H, P243PH, V245E |
| >2029-30724| codons 38-247 CNEMEKEGQISKIGPENPYNTPVFAIKKKSSNRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLAKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRTKIEELRNHLLRWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQHIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |