Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1321 | 1321-30402 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54M, I84V, L90M | L10F, Q58E, G73S, L89V | V11L, T12S, I13V, K14R, I15V, Q18H, L19Q, K20I, E34Q, M36MI, N37S, G51A, D60E, L63P, A71V, P79Q |
| >1321-30402| codons 4-99 TLWQRPFLSVRVGGHQIEALLDTGADDTVLQEISLPGRWKPKMIGGIAGFMKVREYEQIP IEICGHKVISTVLVGQTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | Y188L | T39TA, K43E, E44D, S68G, K82R, V118I, K122E, I135T, T139K, S162A, R172K, R211K, K223T, E224D | E53EK |
| >1321-30402| codons 38-247 CAELEEDGKISKIGPKNPYNTPVFAIKKKDGTKWRKVVDFRELNRRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNEKPGIRYQYNVLPQGWKGSP AIFQASMTKILEPFKKQNPDIVIYQYMDDLLVGSDLEIGQHRTKIEELRQHLWKWGFYTP DKKHQTDPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |