Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1976 | 1976-30604 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, I84V, L90M | G73T | L10I, K20R, E35D, M36I, N37E, R57K, I62IV, L63P, C67F, H69R, A71V, P79AS, I85V, I93L, C95V |
| >1976-30604| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVLEDIELPGRWKPKIVGGIGGFMKVKQYDQVP IEIFGRKVITTVLVGSTPVNVVGRNLMTQLGVTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, M184V, L210W, T215Y | L100I, K103N | K43N, D123E, Q174R, E203K, Q207D, R211RK, L228H |
| >1976-30604| codons 38-247 CTELENEGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPDIVIYQYVDDLYVGSDLEIGQHRTKIKELRDHLWKWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |