Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1900 | 1900-30527 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | G73S | L10I, I15V, K20R, E35D, M36I, R57K, D60E, I62V, L63P, A71V, I72IL |
| >1900-30527| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVKQYEQVP IEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LIV, M184V, L210W, T215Y | K219N | K103N | A98G | V118I, K122E, T200A, H208HY, R211Q | D186DY |
| >1900-30527| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDYLYVGSDLEIGQHRAKIEELRQYLWQWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |