Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1676 | 1676-30331 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184MV, L210W, T215Y | K219N | Y181C, G190A | E44D, V118I, K122E, I135T, V179I, T200A, D218E, V245K |
| >1676-30331| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIICQYVDDLYVASDLEIGQHRAKIEELRQHLWRWGFYTP ENKHQKEPPFLWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54LV, I84V, L90M | L33F, Q58E, G73S | L10I, I13V, Q18E, K20R, E35D, M36I, K55KR, L63P, I66IL, A71V, I93L |
| >1676-30331| codons 4-99 TLWQRPIVTVKIGGELREALLDTGADDTVFEDINLPGRWKPKMIGGIGGFVRVREYDQIP IELCGHKVISTVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |