Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1669 | 1669-30319 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82A, L90M | L33F, F53L, Q58E | L10I, K20R, E35D, M36I, R41K, I62V, L63P, A71V, I93L |
| >1669-30319| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVFEDINLPGKWKPKIVGGIGGLVKVREYDQVP IEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L210W, T215Y | K103N, Y181C | A98G | T39A, E40F, K43E, E79D, K82R, R83K, K122P, I178L, I195IK, E203K, H208Y, R211K, K223E, L228R |
| >1669-30319| codons 38-247 CAFLEEEGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRDLNRKTQDFWEVQLGIPHP GGLKKNKSVTVLDVGDAYFSVPLDPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDLVICQYMDDLYVGSDLEKGQHRTKIKELRQYLWKWGFYTP DKKHQEEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |