Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1024 | 1024-30513 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 8 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75VAIT, M184V, L210W, T215Y | K219N | K103N, G190A | T39A, E44D, V106I, V118I, K122E, T200A, E203D, H208HY, R211RK, D218E, V245T |
| >1024-30513| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHP AGLKKNKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVASDLEIGQHRAKIDELRQYLWKWGFYTP ENKHQKEPPFLWMGYELHPDKWTVQPITLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76LV, V82F, L90LM | L33F, Q58E | L10V, I13V, E35D, M36I, R57K, I62V, L63S, L89M |
| >1024-30513| codons 4-99 TLWQRPVVTVKIGGQLKEALLDTGADDTVFEDINLPGRWKPKIIGGIGGFIKVKEYDQVS IEICGHKAIGTVVVGPTPFNIIGRNMMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |