<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2395 2395-30807 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 1

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K65R, T69D, Q151M, T215Y D67T, K219KE L100I, K103N   E79D, K102KR, K122E, R172K, I178IM, T200A, E203D, Q207A, R211A, H221Y, L228LR V111L, N137NI
>2395-30807| codons 38-247
CTELEKEGKISKIGPENPYNTPVFAIKRKTSDKWRKLVDFRDLNKRTQDFWEVQLGIPHP
AGIKRNKSVTVLDLGDAYFSVPLDEDFRKYTAFTIPSINIETPGIRYQYNVLPMGWKGSP
AIFQSSMTKILEPFKKQNPDMVIYQYMDDLYVGSDLEIGQHRAKIDELRAHLLAWGFYTP
DEKYQKEPPFRWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54M, L76V, I84V, L90M L10F I15V, K20I, E34K, E35D, M36I, R57K, Q61H, L63P, A71V, I72L, I85V  
>2395-30807| codons 4-99
TLWQRPFVTIKVGGQLIEALLDTGADDTVLKDINLPGRWKPKIIGGIGGFMKVKQYDHIP
IEICGHKVLGTVVVGPTPVNVVGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006