Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2395 | 2395-30807 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 1 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K65R, T69D, Q151M, T215Y | D67T, K219KE | L100I, K103N | E79D, K102KR, V111L, K122E, R172K, I178IM, T200A, E203D, Q207A, R211A, H221Y, L228LR | N137NI |
| >2395-30807| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKRKTSDKWRKLVDFRDLNKRTQDFWEVQLGIPHP AGIKRNKSVTVLDLGDAYFSVPLDEDFRKYTAFTIPSINIETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFKKQNPDMVIYQYMDDLYVGSDLEIGQHRAKIDELRAHLLAWGFYTP DEKYQKEPPFRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L76V, I84V, L90M | L10F | I15V, K20I, E34K, E35D, M36I, R57K, Q61H, L63P, A71V, I72L, I85V |
| >2395-30807| codons 4-99 TLWQRPFVTIKVGGQLIEALLDTGADDTVLKDINLPGRWKPKIIGGIGGFMKVKQYDHIP IEICGHKVLGTVVVGPTPVNVVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |