Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1645 | 1645-30313 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82A, I84V, L90M | L33F, K43T, T74P | L10V, V11VL, I13V, K20R, E35D, M36I, N37D, R41RK, K55R, R57K, I62V, L63P, A71V, I93L | E34DY |
| >1645-30313| codons 4-99 TLWQRPVLTVKIGGQLREALLDTGADDTVFYDIDLPGKWTPKLIGGIGGFLRVKQYDQVP IEICGHKVIGPVLVGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K219N | K101DEHQ, Y181C, G190A | F227FL | T39TK, K43E, E44AD, V111I, V118I, T165TI, E203K, Q207QE, H208Y, R211K, K223Q, L228R |
| >1645-30313| codons 38-247 CKELEEDGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDIGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMIKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRTKIKELREYLWKWGFYTP DNKHQQEPPLRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |