<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1645 1645-30313 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54L, V82A, I84V, L90M L33F, K43T, T74P L10V, V11VL, I13V, K20R, E35D, M36I, N37D, R41RK, K55R, R57K, I62V, L63P, A71V, I93L E34DY
>1645-30313| codons 4-99
TLWQRPVLTVKIGGQLREALLDTGADDTVFYDIDLPGKWTPKLIGGIGGFLRVKQYDQVP
IEICGHKVIGPVLVGPTPANVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y K219N K101DEHQ, Y181C, G190A F227FL T39TK, K43E, E44AD, V111I, V118I, T165TI, E203K, Q207QE, H208Y, R211K, K223Q, L228R  
>1645-30313| codons 38-247
CKELEEDGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLQKKKSVTVLDIGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMIKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRTKIKELREYLWKWGFYTP
DNKHQQEPPLRWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006