<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1006 1006-30310 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32VI, I47IV, I54LV, V82A, I84V, L90M L33F, Q58E, L89LV L10I, I15V, L19LI, K20R, E35D, M36L, N37D, R57K, I62V, L63P, A71V, I72IL, I85V, Q92K  
>1006-30310| codons 4-99
TLWQRPIVTIKVGGQIREALLDTGADDTIFEDLDLPGRWKPKMVGGIGGFVKVKEYDQVP
IEICGHKVLGTVLVGPTPANVVGRNVMTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W T215D     K43Q, E44D, V60I, V118I, K122E, S162Y, I178F, Q197K, T200A, Q207N, R211K, E224DN  
>1006-30310| codons 38-247
CTELEQDGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQYSMTKILEPFRKQNPDFVIYQYMDDLYVGSDLEIGKHRAKIEELRNHLWKWGFDTP
DKKHQKNPPFLWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006