Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1006 | 1006-30310 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, I47IV, I54LV, V82A, I84V, L90M | L33F, Q58E, L89LV | L10I, I15V, L19LI, K20R, E35D, M36L, N37D, R57K, I62V, L63P, A71V, I72IL, I85V, Q92K |
| >1006-30310| codons 4-99 TLWQRPIVTIKVGGQIREALLDTGADDTIFEDLDLPGRWKPKMVGGIGGFVKVKEYDQVP IEICGHKVLGTVLVGPTPANVVGRNVMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W | T215D | K43Q, E44D, V60I, V118I, K122E, S162Y, I178F, Q197K, T200A, Q207N, R211K, E224DN |
| >1006-30310| codons 38-247 CTELEQDGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDFVIYQYMDDLYVGSDLEIGKHRAKIEELRNHLWKWGFDTP DKKHQKNPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |