Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1001 | 1001-30227 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48GASW, I54T, V82A | L33F | L10I, V11L, G16A, L19V, K20R, E34Q, E35D, M36I, N37E, D60E, L63P, I64IL, A71V, V77I, L89I, I93L |
| >1001-30227| codons 4-99 TLWQRPILTIKIAGQVREALLDTGADDTVFQDIELPGRWKPKMIWGIGGFTKVRQYEQIP LEICGHKVIGTVLIGPTPANIIGRNILTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69DE, L74LV, L210W, T215Y | D67G, K219KR | E44D, V60I, S68SG, V118I, K122E, D123DE, S162A, D177E, I178M, T200S, Q207E, R211K |
| >1001-30227| codons 38-247 CTELEKDGKISKIGPENPYNTPIFAIKKKGGEKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQASMTKILEPFRKQNPEMVIYQYMDDLYVGSDLEIGQHRSKIEELREHLWKWGFYTP DRKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |