Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2415 | 2415-30821 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L210W, T215Y | K219Q | Y188L | E44D, V118VI, K122E, R172K, D177E, I178M, T200TA, E203K, Q207E, R211K, K223Q, L228H |
| >2415-30821| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFKKQNPEMVIYQYMDDLLVGSDLEIGQHRAKIKELREHLWKWGFYTP DQKHQQEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, V82VF, L90M | F53L, G73T | L10I, L19I, K43R, I62V, L63P, I66IL, A71AV, V77I, I93L |
| >2415-30821| codons 4-99 TLWQRPIVTIKIGGQIKEALLDTGADDTVLEEMNLPGRWRPKIIGGIGGLVKVRQYDQVP IELCGHKVITTVLIGPTPFNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |