Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2412 | 2412-31119 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 14 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, V82AT, L90M | K43T, F53L, G73S | L10I, I15V, K20R, E35D, M36I, R41K, L63P, A71V, I72V |
| >2412-31119| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTILEDINLPGKWTPKIVGGIGGLVKVRQYD QIPIEICGHKVVSTVLVGPTPTNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219R | P4Q, E28K, K32E, V35M, E44D, V111I, V118I, K122E, I178L, T200A, E203D, Q207D, H208F, R211K, A272P, K275R, K277R, T286A, E297K, D324E, G333E, Q334H, G335S, M357V, V365I, A371V, K390R, E399D |
| >2412-31119| codons 1-399 PISQIETVPVKLKPGMDGPKVKQWPLTKEKIEALMEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDIGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYVDDLYVGSDLEIGQHRAKIDELRDFLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQEHSQWTYQIYQEPFKNLKTGKYARVRGA HTNDIKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |