<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2412 2412-31119 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 14

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54V, V82AT, L90M K43T, F53L, G73S L10I, I15V, K20R, E35D, M36I, R41K, L63P, A71V, I72V  
>2412-31119| codons 1-99
PQITLWQRPIVTIKVGGQLREALLDTGADDTILEDINLPGKWTPKIVGGIGGLVKVRQYD
QIPIEICGHKVVSTVLVGPTPTNIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219R     P4Q, E28K, K32E, V35M, E44D, V111I, V118I, K122E, I178L, T200A, E203D, Q207D, H208F, R211K, A272P, K275R, K277R, T286A, E297K, D324E, G333E, Q334H, G335S, M357V, V365I, A371V, K390R, E399D  
>2412-31119| codons 1-399
PISQIETVPVKLKPGMDGPKVKQWPLTKEKIEALMEICTELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDIGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
YQYVDDLYVGSDLEIGQHRAKIDELRDFLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGAKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQEHSQWTYQIYQEPFKNLKTGKYARVRGA
HTNDIKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006