Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2412 | 2412-30812 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, V82A, L90M | K43T, F53L, G73GS | L10I, I15V, K20R, E35D, M36I, R41K, L63P, A71V, I72V |
| >2412-30812| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTILEDINLPGKWTPKIVGGIGGLVKVRQYDQIP IEICGHKVVSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219KR | E44D, K102KR, V111I, V118I, K122E, I178L, T200A, E203D, Q207D, H208F, R211K |
| >2412-30812| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKRKKSVTVLDIGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDLVIYQYVDDLYVGSDLEIGQHRAKIDELRDFLWKWGFYTP DRKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |