Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4023 | 4023-30529 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, I84V | L89V | L10I, V11VL, I13V, K20IM, L33L_L, M36I, R41RK, K43KR, D60E, I62V, L63P, A71V, Q92K |
| >4023-30529| codons 4-99 TLWQRPILTVKIGGQLMEALLDTGADDTVLEEINLPGKWRPKMIGGIGGFVKVRQYEQVP IEICGHKVIGTVLVGPTPANVIGRNVLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, L210LW, T215FY | K219N | K103KN, Y181C, G190A | V108I | E44ED, K122E, D123E, I135V, N175H, D177E, G196E, T200A, K201I, E203D, E204Q, Q207QE, H208Y, R211K, H221Y |
| >4023-30529| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSVPLDEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQHPEIVICQYMDDLYVASDLEIEQHRAIIDQLREYLWKWGFYTP DNKYQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |