Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4077 | 4077-30318 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K103N | T39A, E44D, A98S, V118I, K122E, I135T, Q197E, T200R, Q207K, R211D | I63K |
| >4077-30318| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAKKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGEHRRKIEELRKHLWDWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, L90M | M46V | L10V, K14R, R41K, D60E, L63P |
| >4077-30318| codons 4-99 TLWQRPVVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKVIVGIGGFIKVRQYEQIP IEICGHKAIGTVLVGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |