Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-4070 | 4070-30226 | Australia | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54ILM, L76V, I84V | L10FI, L24LI, L89LV | I13V, K20T, E34K, M36MI, L63P, A71V, I72L, V77I |
| >4070-30226| codons 4-99 TLWQRPIVTVKIGGQLTEALIDTGADDTVLKEINLPGRWKPKIIGGIGGFMKVRQYDQIP IEICGHKVLGTVVIGPTPVNVIGRNVLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, M184V, L210W, T215Y | V75VL | K101P, V106VA, G190A | E44D, V118VI, K122E, V179VI, T200TA, Q207E, H208Y, R211K, D237DN |
| >4070-30226| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKDSTKWRKVLDFRELNKRTQDFWEVQLGIPHP AGLPKKKSATVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYVDDLYVASDLEIGQHRAKIEELREYLWKWGFYTP DKKHQKEPPFLWMGYELHPNKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |