Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1556 | CA71564 | U.S. | 2006 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 109 |
| 2 | AZT+DDC | 14 |
| 3 | DDI | 27 |
| 4 | D4T | 21 |
| 5 | 3TC+AZT | 58 |
| 6 | 3TC+AZT+IDV | 48 |
| 7 | D4T+NFV | 25 |
| 8 | DDC+NFV+RTV+SQV | 16 |
| 9 | 3TC+RTV+SQV | 5 |
| 10 | ABC+EFV+RTV+SQV | 44 |
| 11 | ABC+APV+D4T+RTV | 37 |
| 12 | 3TC+EFV+NVP | 15 |
| 13 | 3TC+EFV+LPV+NVP | 56 |
| 14 | APV+D4T+DDI+IDV | 49 |
| 15 | EFV+NVP+TDF | 65 |
| 16 | 3TC+ABC+AZT+LPV+SQV+TDF | 31 |
| 17 | 3TC+ABC+AZT+RTV+TDF+TPV | 104 |
| 18 | ATV+FTC+RTV+T20+TDF | 52 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I54IV, I84V, L90M | L10F, V11I, L33F, G73S, L89V | T12P, I13V, I15V, L19P, K20T, E35G, M36I, I62V, L63P, K70T, A71I, P79A |
| >CA71564| codons 1-99 PQITLWQRPFIPVKVGGQPTEALLDTGADDTIFEGINLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHTIISTVLVGATPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | A62V, T69G | L100I, K103N | K43KE, K64R, V111VI, K122E, I135T, S162Y, M164L, H208L, R211K, H221HY, L228H, V245E, A272P, K277R |
| >CA71565| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FVIRKKDSGKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDIGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSLTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQLLWKWGFYTPDKKYQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| K7R, S17N, L101I, K111Q, T206S, D256E |
| >CA124203| codons 1-288 FLDGIDRAQEEHEKYHNNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVQTIHTDNGSN FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIVDIIASDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSEIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |