Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 98ZA528 | 98ZA528 | South Africa | 1998 | HIV1 | CRF49_cpx | PBMC | Genomic |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, V31I, L45Q, M50I, I72V, P90S, F100Y, L101I, T112V, S119T, T124A, T125A, K136Q, Q216R, T218I, K219Q, L234I, D278A | S283G |
| >98ZA528| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQQKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVISAETGQETAYYILKLAGRWPVKVIHTDNGTN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKRIIQIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I47M | T12S, I15V, G16E, L19T, M36I, L63P, H69K, L89M, I93L |
| >98ZA528| codons 1-99 PQITLWQRPLVSIKVEGQTKEALLDTGADDTVLEEINLPGRWKPKMMGGIGGFIKVRQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39E, E40D, S48T, K122E, D123S, K173A, D177G, T200A, Q207E, R211K, V245Q, K277R, T286A, E291D, V292I, P294S, Q334H, G335D, R356K, G359T, T377M, K390R, A400T, E404D, V435A, A437V, V466I, S468T, D471E, T477S, H483Q, L491S, S519N, K530R, A534S, A554S |
| >98ZA528| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEDMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPGIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTDIISLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGVETFYVDGAANRETKLGKAGYVTDRGRQKIVTLTETTNQKSELQ AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Hunt, GM | Characterization of near-full length genome sequences of three south African human immunodeficiency virus type 1 subtype C isolates. | Virus Genes, 2003 |