Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| BREPM275 | BREPM275 | Brazil | 1999 | HIV1 | B | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | RTI|PI | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| V151I | S17N, L28I, I72V, L101I, T112I, T124A, Q177L, T218I, L234V, D256E |
| >BREPM275| codons 1-288 FLDGIDKAQEEHEKYHNNWRAMASDFNIPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKIIHTDNGSN FTSATVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVLMAV FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPVWKGPAK LLWKGEGAVVIQDNSEIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | L33F, N88D | L10V, T12K, I13V, I15V, K20T, E35D, M36L, N37E, K55R, R57K, D60E, Q61N, L63S, L89M |
| >BREPM275| codons 1-99 PQITLWQRPVVKVKVGGQLTEALLDTGADNTVFEDLELPGRWKPKMIGGIGGFIRVKQYE NISIEICGHKAIGTVLVGPTPVNIIGRDMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, L210W, T215Y | K103N | V108I | K20R, L34I, V35M, T39A, E40F, K43E, V60I, V118I, K122E, D123E, D177N, G196E, H208Y, R211K, A272P, K281R, P294S, E297K, E312Q, R358K, A360T, K390R, E399D, A400I, V417I, K431T, V435P, A446S, N447S, L452M, T470M, H483Q, L491S, L517V, A534S, A554S |
| >BREPM275| codons 1-560 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKAIMEICAFLEEEGKISKIGPENPYNTPI FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI YQYMDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVISLTKEAE LELAENREILKQPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGT HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWDIWWTEYWQATWIPEWEFINTP PLVKLWYQLETEPIPGAETFYVDGASSRETKMGKAGYVTDRGRQKVVSLMDTTNQKTELQ AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESEVVSQIIEQLIKKEKVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| de Sa Filho, DJ | Analysis of full-length human immunodeficiency virus type 1 genome reveals a variable spectrum of subtypes B and f recombinants in Sao Paulo, Brazil. | ARHR, 2005 |