<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
BREPM119 BREPM119 Brazil 2002 HIV1 F PBMC None

Treatment History
Order Regimen Weeks
1 RTI|PI NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
  L68V E11D, S17N, A21S, V31I, E48K, I72V, L74I, I84L, A98G, L101I, K111R, S119P, T122I, T125A, G163E, V165I, V201I, A205S, K211R, S230N, L234I, D256E  
>BREPM119| codons 1-288
FLDGIDKAQEDHEKYHNNWRSMASDFNLPPIVAKEIVASCDKCQLKGKAMHGQVDCSPGI
WQLDCTHVEGKVIIVAVHVASGYLEAEVIPAETGQETGYFILKLAGRWPVRTIHTDNGPN
FISTAVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIEQIRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIISTDIQTRELQKQITKIQNFRVYYRDNRDPIWKGPAK
LLWKGEGAVVIQDNSEIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12E, I15V, E35D, M36I, R41K, R57K, D60E, Q61N, L89M  
>BREPM119| codons 1-99
PQITLWQRPLVEIKVGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYE
NILIEICGHKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   G190A   K101Q, I142T, L228H, V245M, A272P, T286A, I293V, E297K, M357T, S379G, T386I, K390R, E399D, A400T, K431T, V435A, A446S, L452K, V466A, S468P, D471E, T477A, Q480H, H483Q, L491S, S519N, Q524H, E529T, A534S, I556V, V559I  
>BREPM119| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVASDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFHWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEAVQKIATEGIVIWGKIPKFRLPIQKETWDTWWTEYWQATWIPEWEFVNTP
PLVKLWYQLETEPIAGAETFYVDGASNRETKKGKAGYVTDRGRQKAVPLTETTNQKAELH
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEHLIKKTKVYLSWVPAHK
GIGGNEQVDKLVSAGVRKIL

References
Author Title Citation
de Sa Filho, DJ Analysis of full-length human immunodeficiency virus type 1 genome reveals a variable spectrum of subtypes B and f recombinants in Sao Paulo, Brazil. ARHR, 2005