Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| BREPM108 | BREPM108 | Brazil | 1999 | HIV1 | F | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | RTI|PI | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| L68I | E11D, S17N, I72V, L74I, I84L, L101I, K111R, S119T, T125A, M154I, V165I, Q177L, F181Y, V201I, A205S, K211R, T218I, L234V, D256E | S283G |
| >BREPM108| codons 1-288 FLDGIDKAQEDHEKYHNNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHIEGKVIIVAVHVASGYLEAEVIPAETGQETAYFILKLAGRWPVRTIHTDNGTN FTSTAVKAACWWAGIKQEFGIPYNPQSQGVVESINKELKKIIGQIRDQAEHLKTAVLMAV YIHNFKRKGGIGGYSAGERIIDIISTDIQTRELQKQIIKIQNFRVYYRDSRDPVWKGPAK LLWKGEGAVVIQDNSEIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, E35D, M36I, R41K, R57K, Q61N, L89M, I93L |
| >BREPM108| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD NILIEICGHKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | P4Q, K20R, V118I, D121H, K122E, I135T, Q174H, F214L, A272P, K281R, E297K, S322T, I329L, E399D, A400L, K431T, V435A, A446S, L452T, V466A, S468P, D471E, T477A, H483Q, L491S, Q507L, L517I, S519N, A534S |
| >BREPM108| codons 1-560 PISQIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPTKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWDLWWTEYWQATWIPEWEFVNTP PLVKLWYQLETEPIAGAETFYVDGASNRETKTGKAGYVTDRGRQKAVPLTETTNQKAELQ AIQLALQDSGSEVNIVTDSQYALGIILAQPDKSESEIVNQIIEQLIKKEKVYLSWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| de Sa Filho, DJ | Analysis of full-length human immunodeficiency virus type 1 genome reveals a variable spectrum of subtypes B and f recombinants in Sao Paulo, Brazil. | ARHR, 2005 |