Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| TV002_12_5_1C | 02_12_5_1C | South Africa | 1999 | HIV1 | C | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, V31I, I84M, L101I, T112V, T125A, G134D, K136Q, Q137R, V201I, T206S, T218I, L234I, R269K, D278A | S283G |
| >02_12_5_1C| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYMEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGSN FTSTAVKAACWWADIQREFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIKDYGKQMAGADCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, G16A, L19T, M36I, R41K, H69K, K70R, I93L |
| >02_12_5_1C| codons 1-99 PQITLWQRPLVSIKVAGQTKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QILIEICGKRAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, T39E, S48T, K122E, D123S, K166R, K173T, D177E, I178V, T200A, Q207G, R211K, V245Q, D250E, A272P, K277R, T286A, E291D, V292I, I293V, Q334N, G335D, K350R, R356K, G359T, T369A, A376T, T377Q, K390R, Q394P, A400T, T403S, E404D, L452I, R461K, L469F, D471E, H483Q, L491P, A534S, A554S |
| >02_12_5_1C| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRTQNPEVVI YQYMDDLYVGSDLEIGQHRAKIEELRGHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLRTGKYAKMRTA HTNDVKQLAEAVQKITQESIVIWGKTPKFRLPIPKETWETWWSDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKIGKAGYVTDKGRQKVVSFTETTNQKTELQ AIQLALQDSGPEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Megede, JZ | Novel evolutionary analyses of full-length HIV type 1 subtype C molecular clones from Cape Town, South Africa. | ARHR, 2002 |