<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
EC102 EC102 Ecuador 1990 HIV1 B PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    S17N, L28I, P30A, G106A, V201I, L234I, D253E, D256E  
>EC102| codons 1-288
FLDGIDKAQEEHEKYHNNWRAMASDFNIPAVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAARWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQENSEIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12Q, L19V, N37D, K43R, A71T  
>EC102| codons 1-99
PQITLWQRPLVQIKIGGQVKEALLDTGADDTVLEEMDLPGRWRPKMIGGIGGFIKVRQYD
QILIEICGHKTIGTVLVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K11R, K20R, K122E, D123N, I135T, T200I, I202V, R211K, V245M, A272P, I293V, F346Y, M357V, A376T, T386I, K388H, T403V, V435T, L452S, Q480H, H483N, L491S, K512R, V531T, A554S  
>EC102| codons 1-560
PISPIETVPVRLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRIKVEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPYKNLKTGKYARVRGA
HTNDVKQLTEAVQKITTESIVIWGKIPHFKLPIQKETWEAWWVEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPITGAETFYVDGAANRETKSGKAGYVTDRGRQKVVSLTDTTNQKTELH
AINLALQDSGSEVNIVTDSQYALGIIQAQPDRSESELVSQIIEQLIKKEKTYLAWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Hierholzer, J Molecular epidemiology of HIV type 1 in Ecuador, Peru, Bolivia, Uruguay, and Argentina. ARHR, 2002