<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
X1241 X1241 Spain 2002 HIV1 F PBMC None

Treatment History
Order Regimen Weeks
1 RTI NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
  G163K S17N, I72V, I84L, L101I, S119T, T122S, T124A, T125A, K136Q, D167E, V201I, T218I, L234V, D253E, D256E  
>X1241| codons 1-288
FLDGIDKAQEEHEKYHNNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYLEAEVIPAETGQETAYFILKLAGRWPVKTIHTDNGTN
FSSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIKQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQENSEIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12E, I15V, L19I, E35N, M36I, R41K, R57K, Q61D, I72T, I93L  
>X1241| codons 1-99
PQITLWQRPLVEIKVGGQIKEALLDTGADDTVLENINLPGKWKPKMIGGIGGFIKVKQYD
DILIEICGHKATGTVLVGPTPVNIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
  K219R     V35T, V60I, I135T, Q197K, T200E, Q207E, F214L, A272P, K281R, E297K, K311R, S322L, D324E, R358K, A376T, K390R, Q394L, E399D, A400T, T403S, K431T, V435A, G436E, A446S, L452A, D471E, T477A, Q480H, H483Q, L491S, S519N, K527N, A534S, A554S  
>X1241| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGKHREKIEELREHLLRWGLTTPDRKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVIPLTKEAE
LELAENREILREPVHGVYYDPLKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFRLPILKETWDTWWSEYWQATWIPEWEFVNTP
PLVKLWYQLETEPIAEAETFYVDGASNRETKAGKAGYVTDRGRQKVVSLTETTNQKAELH
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKEKVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Sierra, M The analysis of near full-length genome sequences of human immunodeficiency virus type 1 BF intersubtype recombinant viruses from Chile, Venezuela and Spain reveals their relationship to diverse lineages of recombinant viruses related to CRF12_BF. Infect Genet Evol, 2004