<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
JH_Du179 JH_Du179 South Africa 1999 HIV1 C PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    D25E, V31I, L45Q, I72V, I84M, F100Y, L101I, T112V, T124S, T125A, K136Q, V201I, T218I, S230N, L234I, A265V, D278A S283G
>JH_Du179| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQQKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYMEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSSAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDNRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, K14R, I15V, L19I, M36I, N37D, R41K, H69K, L89M, I93L  
>JH_Du179| codons 1-99
PQITLWQRPLVSIRVGGQIKEALLDTGADDTVLEEIDLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K32R, V35T, E36A, T39E, E40D, S48T, V60I, K122E, K173A, D177E, T200A, Q207E, R211K, V245N, E248D, A272P, K275Q, K277R, T286A, E291D, V292I, I293V, D324E, Q334D, G335D, R356K, M357R, G359T, A376S, T377L, S379C, K390R, A400I, E404D, E432D, V435L, V458I, T470R, D471E, H483Q, L491S, S519N, Q524E, K530R, A534S, A554S  
>JH_Du179| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIRALTAICEDMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPINLPDKDSWTVNDIQKLVGKLNWASQIYPGIQVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGDDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVKQLTEAVQKISLECIVIWGKTPKFRLPIQKETWEIWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKDPILGAETFYVDGAANRETKLGKAGYITDRGRQKVVSLRETTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEELIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
van Harmelen, J, Characterization of full-length HIV type 1 subtype C sequences from South Africa. ARHR, 2001