Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CO346 | CO346 | Tanzania | 2004 | HIV1 | A | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| I72V, L101I, T112V, I113V, T124A, T125A, G134D, K136Q, D167E, V201I, I208M, E212A, Q221P | S283G |
| >CO346| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVVHTDNGSN FTSAAVKAACWWADIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDMQTKALQKQITKIPNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19V, M36I, R41K, L63P, H69K, L89M, I93L |
| >CO346| codons 1-99 PQITLWQRPLVSIKVGGQVKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| E6D, V35T, V60I, K122E, D123S, K173A, I178M, G196E, T200A, E204K, Q207E, R211K, V245H, D250E, A272S, E291D, V292I, I293V, V314T, Q334N, G335D, R356K, T377M, K390R, A400T, E404D, V435I, A437V, L452I, L469I, D471E, H483Q, L491S, S519N, K530R, A534S, A554S |
| >CO346| codons 1-560 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPDMVI YQYMDDLYVGSDLEIEQHRAKIEKLREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIHLPEKESWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPTHGVYYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTEAVQKIAMESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIIGVETFYVDGAANRETKIGKAGYVTDRGRQKVVSITETTNQKTELQ AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Arroyo, MA | HIV-1 diversity and prevalence differ between urban and rural areas in the Mbeya region of Tanzania. | AIDS, 2005 |