<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
Cu74 Cu74 Cuba 1999 HIV1 G PBMC None

Treatment History
Order Regimen Weeks
1 Unknown NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K14R, V31I, V32I, L101I, T112V, T124A, T125A, G134N, K136T, V201I, T206S, Y227F, L234I, S255N, D256E, D279A S283G
>Cu74| codons 1-288
FLDGIDKAQEEHERYHSNWRAMASDFNLPPIIAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWANITQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIASDIQTKELQKQITKIQNFRVYFRDSRDPIWKGPAK
LLWKGEGAVVIQDNNEIKVVPRRKAKIIRDYGKQMAGDACVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89M  
>Cu74| codons 1-99
PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPINIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
      V179E V21I, V35T, E36D, T39A, E40D, I50F, V60I, I135T, D177E, T200A, R211S, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, D324E, L325I, I329V, Q334N, G335D, F346Y, R356K, M357R, R358G, G359S, T369V, A371V, A376S, Q394R, A400V, E404D, E413D, Q428R, K431T, V435L, F440Y, R461N, R463K, V467I, S468T, H483Q, L491S, K512R, S519N, A534S, A554T  
>Cu74| codons 1-560
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALTDICADMEKEGKISKFGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIEI
YQYMDDLYVGSDLEIGQHRAKIEELRQHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKEIIAEVQKQGNDQWTYQIYQEPYKNLKTGKYAKRGSA
HTNDVKQLVEVVQKISTESIVIWGKTPKFKLPIRKETWEVWWTDYWQATWIPDWEFVNTP
PLVKLWYRLETEPILGAETYYVDGAANRETKLGKAGYVTDNGKQKVITLTDTTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDRSESELVNQIIEQLIKKEKVYLSWVPAHK
GIGGNEQVDKLVSTGIRKVL

References
Author Title Citation
Sierra, M Identification of 3 phylogenetically related HIV-1 BG intersubtype circulating recombinant forms in Cuba. JAIDS, 2007