Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MSA4080 | MSA4080 | Kenya | 2000 | HIV1 | A | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| K14R, V31I, M50I, I60M, I72V, T112V, I113V, T124A, T125A, K136Q, D167E, V201I, A265V, I268L | S283G |
| >MSA4080| codons 1-288 FLDGIDKAQEEHERYHSNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGM WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKILRDYGKQMAGDDCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, E35D, M36I, R41K, K45R, H69K, L89M |
| >MSA4080| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEDINLPGKWKPRMIGGIGGFIKVRQYD QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K32N, V35M, E36A, T39E, S48T, K122E, D123N, I135R, K166R, K173T, T200A, Q207E, V245Q, K277R, T286A, I293V, P294T, G335D, M357R, G359S, T362S, T369A, A371V, I375V, A376V, T377M, T386A, A400I, T403M, E404D, E432D, V435A, T470A, D471E, K476R, Q480H, H483Y, L491S, K512R, S519N, Q524K, K527G, E529D |
| >MSA4080| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALMAICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRTQNPDIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVTLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARRRSA HSNDVKQLAEVVQKVVMESIVIWGKAPKFKLPIQKETWEIWWMDYWQATWIPEWEFVNTP PLVKLWYQLEKDPIAGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLAETTNQRTELH AIYLALQDSGSEVNIVTDSQYALGIIQAQPDRSESELVNQIIEKLIGKDKVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Dowling, WE | Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. | AIDS, 2002 |