Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MSA4077 | MSA4077 | Kenya | 2000 | HIV1 | C | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| S17N, V31I, M50I, I72V, I84M, F100Y, L101I, T112V, T124Q, T125A, K136Q, I200M, V201I, I208L, T218I, L234I, R269K, D278A |
| >MSA4077| codons 1-288 FLDGIDKAQEEHEKYHNNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYMEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN FTSQAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERMIDIIATDLQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIKDYGKQMAGADCVASRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, L19S, N37K, R41N, L63S, H69K, V77I, V82I, L89M, I93L |
| >MSA4077| codons 1-99 PQITLWQRPLVSIKIGGQSKEALLDTGADDTVLEEMKLPGNWKPKMIGGIGGFIKVRQYD QISIEICGKKAIGTVLIGPTPINIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K11T, V35T, E36A, T39E, E40D, S48T, K49R, K122E, D123G, Q145C, K173A, D177E, T200A, Q207E, V245Q, A272P, K277R, T286A, E291D, V292I, I293V, S322L, G335D, F346H, R356K, G359T, T377Q, K390R, A400T, E404D, V435A, A437V, L452M, R461K, S468A, D471E, H483K, L491S, S519N, A534S, A554N |
| >MSA4077| codons 1-560 PISPIETVPVTLKPGMDGPKVKQWPLTEEKIKALTAICEDMEKEGKITRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNETPGIRYCYNVLPQGWKGSPAIFQSSMTKILEPFRAQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPLKDLIAEIQKQGQDQWTYQIYQEPHKNLKTGKYAKMRTA HTNDVKQLTEAVQKIAQESIVIWGKTPKFRLPIQKETWETWWTDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGVETFYVDGAANRETKMGKAGYVTDKGRQKVVALTETTNQKTELQ AIKLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLSWVPAHK GIGGNEQVDKLVSNGIRKVL |
References
| Author | Title | Citation |
| Dowling, WE | Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. | AIDS, 2002 |