Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| MSA4072 | MSA4072 | Kenya | 2000 | HIV1 | A | PBMC | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| K14R, V31I, I60M, T112V, I113V, T125A, V126F, I135V, K136Q, D167E, V201I | S283G |
| >MSA4072| codons 1-288 FLDGIDKAQEEHERYHSNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAMHGQVDCSPGM WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGSN FTSTAFKAACWWAGVQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L | I13V, K14R, I15V, E35D, M36I, R41K, K55R, R57K, L63P, H69K, L89M |
| >MSA4072| codons 1-99 PQITLWQRPLVTVRVGGQLKEALLDTGADDTVLEDINLPGKWKPKLIGGIGGFIRVKQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| P4S, K11T, K20R, V21I, V35T, T39R, D123N, K173S, D177E, V179I, I202V, Q207A, R211S, V245Q, E248D, T286A, E291D, V292I, I293V, I309V, E312D, V317T, G335D, M357R, G359S, T369A, A371V, I375V, A376V, T377L, A400T, T403M, E404D, E432D, R461K, S468P, T470A, D471E, Q480Y, H483Y, L491S, K512R, S519N, Q524K, K527G, E529D, A534S, A554S, V559I |
| >MSA4072| codons 1-560 PISSIETVPVTLKPGMDGPRIKQWPLTEEKIKALTEICREMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKNFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSQNPEIII YQYMDDLYVGSDLEIGQHRTKVEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVPLTEEAE LELAENREVLKDPVHGTYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARRRSA HTNDVKQLAEVVQKVVLESIVIWGKTPKFKLPIQKETWETWWMDYWQATWIPEWEFVNTP PLVKLWYQLEKDPIVGAETFYVDGAANRETKLGKAGYVTDKGRQKVVPLAETTNQKTELY AIYLALQDSGSEVNIVTDSQYALGIIQAQPDRSESELVNQIIEKLIGKDKVYLSWVPAHK GIGGNEQVDKLVSSGIRKIL |
References
| Author | Title | Citation |
| Dowling, WE | Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. | AIDS, 2002 |